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Surgical site infections are common problems in health care.

The HTA was performed by a group consisting of an infection specialist, a surgeon and a specialist in infection control and hospital hygiene - all with scientific qualifications – working together with the HTA center.

A systematic literature search identified twenty-three articles to be read by the project group. Twelve of those articles were excluded as they did not match the PICO.

Eleven RCTs remained and were assessed regarding quality. Results from the nine studies that were of high or medium quality were included in the meta-analysis (n=3755) and the level of evidence was assessed using the GRADE system. In these studies patients with various surgical operations were included, the Centers for Disease Control and Prevention (CDC) criteria for classification of infections or other defined criteria, were used and assessors were blinded. Majority of the patients had antibiotic prophylaxis.

The relative risk of superficial SSI with triclosancoated sutures in nine studies of high or medium quality was 0.78 (95 % CI 0.64-0.95) p=0.01. If studies of high quality only were included there was no statistical significant difference  0.71 (95% CI 0.46-1.10)p=0.13.

The conclusion of the assessment is that triclosan coated sutures had in various operations a limited beneficial effect with significantly lower incidence of superficial or deep postoperative SSI. The level of evidence according to GRADE was low ⊕⊕.

Included and excluded articles

Search strategy

Search documentation

Report in Swedish